NADPH oxidases regulate CD44 and hyaluronic acid expression
نویسندگان
چکیده
3 The abbreviations used are: ROS, reactive oxygen species; VSMC, vascular smooth muscle cells, HA, hyaluronic acid; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; Has2, hyaluronan synthase 2; Hyal3, hyaluronidase 3; LMW-HA, low-molecular-weight HA; HMW-HA, highmolecular-weight HA; DPI, diphenyleneiodonium chloride; DMNQ, 2,3-Dimethoxy-1,4-naphthoquinone; GKT136901 (2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine3,6(2H,5H)-dione) NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombintreated Vascular Smooth Muscle Cells and in Atherosclerosis Aleksandr E. Vendrov , Nageswara R. Madamanchi ‡ , Xi-Lin Niu , Kimberly C. Molnar , Mason Runge, Cédric Szyndralewiez, Patrick Page and Marschall S. Runge ‡ 2 From the Department of Medicine, McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599-7126, USA, and § GenKyoTex S.A, 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland Running Title: NADPH oxidases regulate CD44 and hyaluronic acid expression
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NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.
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